The objective searched in the use of the anti-cancer treatment is to reach tumoral cells in order to destroy them in a way as selective as possible, while operating one or more targets, all this explains the multiplicity of the research undertaken in the field of cancerology. Progress of molecular biology has allowed the emergence of different therapeutic approaches which deeply do not affect the operation of the healthy cells: immunizing defenses of the organization, cellular differentiation, the angiogenesis and the apoptosis constitute thus the principal explored ways. However, these ways are generally unbalanced by surexpression of a protein having a strong activity Tyrosine kinase, this led to the marketing of anti-cancer non cytotoxic: Imatinib (Imatib^® or Glivec^®) first inhibitor of Tyrosine kinase, this discovery was followed by the introduction of other molecules of the same classe Dasatinib, Nilotinib. The main objective was to evaluate the tolerance with the Inhibitors of Tyrosine Kinase (TKI) among cancer patients