Global Journal of Interdisciplinary Social Sciences(GJISS) is a peer-reviewed International research journal published online. This journal offers a platform for scholars, academicians, professionals and students, to contribute interdisciplinary research from across the fields within the social sciences including, but not limited to : Anthropology, Arts & culture, Communication studies, Criminology, Cross-cultural studies in Demography, Economics, Education, English, Ethics, Geography, History, International relations, Law, Library science, Linguistics, Literature, Media studies, Political science, Psychology, Public administration, Sociology & Philosophy. The journal offers a global platform for the academia to elevate their scholarly image internationally as it reaches a wide spectrum of readers globally.

Childhood trauma is a frequent and significant risk factor for adult major depressive disorder, linked to earlier onset, more persistent or recurrent symptoms, and a higher likelihood of co-occurring disorders. Some studies suggest that patients with a history of childhood trauma may respond less favourably to evidence-based pharmacotherapies and psychotherapies for adult depression than patients without such a history, but results are mixed. In order to find out if people with major depressive disorder, including chronic forms of depression, and a history of childhood trauma had more severe depressive symptoms before treatment, more unfavourable treatment outcomes after active treatments, and were less likely to benefit from active treatments relative to a control condition, compared to people with depression without childhood trauma, we looked at these factors.

We carried out a thorough meta-analysis (PROSPERO CRD42020220139).In order to find English-language papers for the study, researchers combined searches of bibliographical databases (PubMed, PsycINFO, and Embase) with full-text randomised clinical trials (RCTs) located in a number of sources between 1966 and 2016–19.For adult patients with depressive disorders and the presence or absence of childhood trauma, RCTs and open trials comparing the efficacy or effectiveness of evidence-based medication, psychotherapy, or combination interventions were included. Study characteristics were derived by two separate researchers. The authors of the study were asked to provide group data for the estimations of effect sizes. The main result was the change in depression severity from the beginning of the acute treatment phase to the end, as measured by the standardised effect size (Hedges' g).We conducted meta-analyses utilising random-effects models.

We discovered evidence that, in contrast to prior studies, patients with major depressive disorder and childhood trauma experience significant improvements in their symptoms following pharmacological and psychotherapeutic treatments, despite the fact that their depressive symptoms are more severe in general. Regardless of whether a patient has experienced childhood trauma, evidence-based treatment and medication should be provided to them. We discovered evidence that, in contrast to prior studies, patients with major depressive disorder and childhood trauma experience significant improvements in their symptoms following pharmacological and psychotherapeutic treatments, despite the fact that their depressive symptoms are more severe in general.